Home> C-REACTIVE PROTEIN (CRP)
The C Reactive protein, more commonly known as the CRP is a protein produced by the liver in response to inflammation. When there is inflammation in the body due to infection, injury, or chronic diseases, the liver releases more CRP into the bloodstream.
CRP helps the immune system by binding to dead or dying cells and certain bacteria, which facilitates their removal by immune cells. C Reactive protein tests or CRP tests involve using antibodies that specifically bind to CRP, allowing its concentration to be quantified.
A C-Reactive Protein (CRP) test is used to identify various diseases and conditions characterized by inflammation in the body. These include:
- bacterial infections such as pneumonia, urinary tract infections (UTIs), and sepsis.
- Autoimmune Diseases like rheumatoid arthritis, lupus, and vasculitis
- Inflammatory Bowel Disease (IBD): ulcerative colitis and Crohn's disease
- Cardiovascular Diseases, heart attacks and strokes
- chronic inflammatory conditions like osteoarthritis, chronic obstructive pulmonary disease (COPD), and chronic kidney disease
- Post-Surgical Complications
By understanding CRP levels, doctors can gain insight into inflammatory processes in the body, aiding in the diagnosis and monitoring of various medical conditions.
The primary focus of the test is to measure the concentration of C-reactive protein in the bloodstream or CRP levels. Elevated levels indicate inflammation, which could be due to various conditions such as infections, chronic diseases, or acute injuries.
The results are compared against standard reference ranges. Typically, a normal CRP level is less than 10 mg/L, though this can vary slightly between laboratories.
For individuals with chronic conditions or those undergoing regular monitoring, baseline CRP levels are considered to assess changes over time.
In some cases, a high-sensitivity CRP (hs-CRP) test is used, especially to assess the risk of cardiovascular diseases. This test can detect lower levels of CRP, typically below 10 mg/L, and is more precise in identifying low-grade inflammation.
By evaluating these parameters, doctors can diagnose, monitor, and manage inflammatory conditions more effectively.
Doctors may order a C-Reactive Protein (CRP) test for several key reasons including (but not limited to):
Before undergoing a C-Reactive Protein (CRP) test, the following precautions and preparations should be considered:
- Typically, no fasting is required for a standard CRP test. However, if a high-sensitivity CRP (hs-CRP) test is part of a comprehensive assessment for cardiovascular risk, fasting for 9-12 hours might be recommended.
- Inform your doctor about any medications, herbal remedies, or over-the-counter (OTC) supplements you are taking, as certain medications such as Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), Statins (Cholesterol lowering drugs), Immunosuppressive Drugs, Corticosteroids, Hormone Replacement Therapy (HRT) and certain supplements can affect CRP levels.
- If possible, avoid scheduling the test soon after an acute illness or injury, as these can temporarily elevate CRP levels, potentially skewing the results.
- Let your physician know if you have any chronic inflammatory conditions, as these might influence your CRP levels and the interpretation of the results.
Adhere to any specific instructions given by your physician, such as stopping certain medications before the test if advised.
By taking these precautions and preparing appropriately, you can help ensure that the CRP test results are accurate and meaningful for your healthcare assessment.
A C-Reactive Protein (CRP) test is recommended for:
- Those experiencing symptoms like unexplained fever, persistent fatigue, or pain and swelling in joints may need the test to identify underlying inflammatory conditions.
- People with chronic inflammatory conditions such as rheumatoid arthritis, lupus, or inflammatory bowel disease should get regular CRP tests to monitor their condition and treatment response.
- Individuals showing signs of bacterial infections, especially if the source is not clear, may benefit from a CRP test to confirm and evaluate the severity of the infection.
- Patients who have recently undergone surgery may be tested to detect any post-operative infections or complications early.
- People at risk of cardiovascular diseases, including those with a family history of heart disease or other risk factors like high cholesterol, may undergo a high-sensitivity CRP (hs-CRP) test to assess their risk of heart attacks and strokes.
These groups of individuals can benefit from the valuable insights provided by the CRP test, aiding in the diagnosis, monitoring, and management of various health conditions.
In the lab, a technique called immunoassay is typically used to measure the CRP levels in the blood sample. The procured blood sample is mixed with special antibodies that specifically bind to the target protein (e.g., CRP). These antibodies are often linked to a detectable marker, such as a dye or enzyme. When the antibodies bind to the target protein, the marker produces a signal. The strength of the signal is measured. The intensity of the signal corresponds to the amount of the target C Reactive protein in the sample. The measured signal is compared to a standard reference to determine the concentration of the protein in the blood sample.
This method allows for accurate and specific detection of proteins, helping doctors diagnose and monitor various health conditions.
The C-Reactive Protein (CRP) test is generally safe and well tolerated, but there are a few minor risks associated with the blood draw for the CRP test. The risks of C-Reactive Protein test are as follows:
- There might be slight pain or discomfort during the needle insertion and mild bruising and irritation following it.
- Although rare, some people may experience more prolonged bleeding.
- There is a very minimal risk of infection at the puncture site.
- It's possible for certain individuals to become dizzy or pass out during or after the C-Reactive Protein test procedure.
These risks are minor and typically resolve quickly without serious complications.
Normal C Reactive Protein Levels are typically less than 10 mg/L. Low levels of CRP indicate that there is no significant inflammation in the body. This is generally a sign of good health.
Elevated CRP levels indicate the presence of inflammation in the body, though they do not specify the exact cause. Additional tests and clinical evaluation are often needed to determine the underlying condition.
CRP results should be interpreted in the context of other clinical findings and patient history. Elevated CRP alone does not diagnose a specific condition. Acute infections or injuries can cause temporary spikes in CRP levels. Follow-up tests may be necessary to determine if elevated CRP is persistent.
- Mildly Elevated C Reactive Protein Levels between 10 mg/L and 100 mg/L could be possible due to Mild infections, chronic inflammatory conditions (like rheumatoid arthritis or lupus), or lifestyle factors such as smoking or obesity.
- Moderately to Highly Elevated CRP levels above 100 mg/L could be a result of Acute bacterial infections, severe trauma, or major inflammation from conditions such as sepsis or autoimmune diseases.
By understanding CRP levels, doctors can gain insight into inflammatory processes in the body, aiding in the diagnosis and monitoring of various medical conditions.
hs-CRP is used to assess cardiovascular risk. Higher levels indicate an increased risk of heart disease and stroke.
- hs-CRP levels of Less than 1 mg/L indicate a low risk of cardiovascular diseases
- hs-CRP levels between 1 and 3 mg/L signify a moderate risk of cardiovascular diseases
- hs-CRP results above 3 mg/L signify a high cardiovascular risk
Choose from over 5000 diagnostic tests, from routine checkups to advanced radiology tests such as PET CT and 3T MRI. Book appointments instantly, get samples collected at home, and access your medical history - all on your phone using the user-friendly Vijaya Diagnostics app.
Choose Vijaya Diagnostics - because your health deserves nothing less!
Ans) The standard C-Reactive Protein (CRP) test can typically be done at any time of day, as fasting is usually not required. However, it’s advisable to get a high sensitivity C Reactive protein test in the morning as 9-12 hours fasting may be required for the hs-CRP test.
Ans) CRP test results are usually available within a day or two, depending on the laboratory.
Ans) How often you should get a CRP test depends on your health condition and doctor's recommendation. It can vary from regular monitoring for chronic conditions to as needed for acute illnesses.
Ans) The CRP test is used to detect inflammation in the body, helping diagnose infections, monitor chronic diseases like arthritis, assess cardiovascular risk and evaluate post operative recovery.
Ans) Elevated CRP levels can indicate inflammation due to infections, autoimmune diseases, or chronic conditions. Further evaluation is needed to determine the underlying cause and appropriate treatment.
Ans) The normal range for CRP is typically less than 10 mg/L. However, this can vary slightly between laboratories.
Ans) The cost of a C-Reactive Protein Test may significantly vary depending on factors like the diagnostic center or hospital where you get the C-Reactive Protein Test, location of the diagnostic center or hospital, sedative/anesthesia administered during the procedure and whether biopsies or additional procedures performed as part of the C-Reactive Protein Test procedure. The C-Reactive Protein Test test price at Vijaya Diagnostic typically ranges from just INR 2800 to INR 3300. Plus, with app-only discounts and cashbacks, taking care of your health has never been easier or more rewarding.
Ans) The cost of a C-Reactive Protein (CRP) test in India can vary depending on whether it's a standard or high-sensitivity C Reactive Protein test, the laboratory and location of the diagnostic center. The CRP test cost typically ranges from around ₹300 to ₹550 at Vijaya Diagnostics.
Ans) Generally, a CRP level above 10 mg/L is considered elevated and may indicate significant inflammation or infection. However, specific thresholds can vary depending on the clinical context and the type of CRP test used.
Ans) If you are looking for a reliable and affordable diagnostic center to get a C Reactive Protein test near you then look no further than Vijaya Diagnostics. With over 140+ cutting edge labs across 20+ cities, you’re sure to find a Vijaya Diagnostic center near you!
What’s more? We are bringing CRP tests, preventive health checkups and other blood tests right to your doorstep with our home sample collection option. Book a convenient time slot using our app and enjoy exclusive discounts, cashbacks and more on the Vijaya Diagnostic app! You can alternatively call us on 040 - 2100 0000 or choose your preferred test from the Vijaya Diagnostics website.
Ans) Treatment for elevated CRP levels depends on the underlying cause. It may involve addressing infections with antibiotics, managing chronic inflammatory conditions with medications like corticosteroids or disease-modifying drugs, adopting lifestyle changes such as diet and exercise to reduce cardiovascular risk, or addressing other health issues identified through further evaluation.